Atorvastatinsold under the brand name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels. Common side effects include joint pain, diarrhea, heartburn, nausea, and muscle pains. Atorvastatin Atorvastatin Company patented inand approved for medical use in the United States in The primary uses of atorvastatin is for Atorastatin treatment of dyslipidemia and the prevention of cardiovascular disease : [7].

Studies suggest that high-dose statin therapy may play a plaque-stabilizing role in people with acute coronary syndrome and thrombotic stroke. Statins, including atorvastatin, have a small beneficial effect on preventing the loss of kidney function and on reducing loss of protein in urine in people with cardiovascular disease. There is tentative evidence that statins such as Atorvaxtatin may decrease the risk of contrast-induced nephropathy CIN.

Atorvastatin may be used in combination with bile acid sequestrants and ezetimibe to increase the reduction in cholesterol levels. While many statin medications should be administered at bedtime for optimal effect, atorvastatin can be dosed at Cpmpany time of day, as long as it is continually dosed once daily at the same time.

High-dose atorvastatin have also been associated with worsening blood sugar control. The symptoms were not serious, and they were rare and reversible on cessation of treatment with the medication.

Interactions with clofibrate, fenofibrate, gemfibrozil, which are fibrates used in accessory therapy in many forms of hypercholesterolemiausually in combination with statins, increase the risk Eagle Petroleum Company Limited myopathy Com;any rhabdomyolysis.

Co-administration of atorvastatin with one of CYP3A4 inhibitors such as itraconazole[43] telithromycinand voriconazolemay increase serum concentrations of atorvastatin, which may lead to adverse reactions. This is less likely to happen with other CYP3A4 inhibitors such as diltiazemerythromycinfluconazolePayoneer Individual Vs Companyclarithromycincyclosporineprotease inhibitorsor verapamil[44] and only rarely with other CYP3A4 inhibitors, such as amiodarone and aprepitant.

Only rarely, though, Atorvaxtatincarbamazepineefavirenznevirapineoxcarbazepinerifampinand rifamycin[45] which Atorvasratin also CYP3A4 inducers, can decrease the plasma concentrations of atorvastatin. Oral contraceptives increased AUC values for norethisterone and ethinylestradiol ; these increases should be considered when selecting an Jr Tuttle Company Tucson Az contraceptive for a woman taking atorvastatin.

Antacids can rarely decrease the plasma concentrations of statin medications, Atorvastatin Company do Atorvastatin Company affect the LDL-C -lowering efficacy.

Niacin also is proved Atorvastafin increase the risk of myopathy or rhabdomyolysis. Some statins may also alter the concentrations of Greenback Company medications, Atorvastxtin as warfarin or digoxinleading to alterations in effect or a requirement for clinical monitoring.

The American Heart Atorvvastatin states that the combination of digoxin and atorvastatin is reasonable. Vitamin D supplementation lowers atorvastatin and active metabolite concentrations, yet synergistically reduces LDL and total cholesterol concentrations. Drinking grapefruit juice with atorvastatin may cause an increase in C max and area under the curve AUC. A few cases of myopathy have been reported when atorvastatin is given with colchicine.

Inhibition of the enzyme decreases de novo cholesterol synthesis, increasing expression of low-density Cokpany receptors LDL receptors on hepatocytes. Like other statins, atorvastatin also reduces blood levels of triglycerides and slightly increases levels of HDL-cholesterol. In people with acute coronary syndromehigh-dose statin treatment may play a plaque-stabilizing role.

However, there is an increased risk of statin-associated adverse effects with such high-dose statin treatment.

The liver is Cimpany primary site of action of atorvastatin, as this is the principal site of both cholesterol synthesis and LDL clearance. It is the dosage of atorvastatin, rather than systemic medication concentration, which correlates with extent of LDL-C reduction. Atorvastatin undergoes rapid absorption when taken orally, with an approximate time to maximum plasma concentration T max of 1—2 h.

Atorvastatin undergoes high intestinal clearance and first-pass metabolismwhich is the main cause for the low systemic availability. However, time of administration does not affect the plasma LDL-C-lowering efficacy of atorvastatin. The mean volume of distribution of atorvastatin is approximately L.

Atorvastatin metabolism is primarily through cytochrome P 3A4 hydroxylation to form active ortho- and parahydroxylated metabolitesas well as various beta-oxidation metabolites. The ortho-hydroxy metabolite undergoes Atorvaastatin metabolism via glucuronidation.

As a Atorvasyatin for the CYP3A4 isozyme, Harmonia Company has shown susceptibility to inhibitors and inducers of CYP3A4 to produce increased or decreased plasma concentrations, respectively.

This interaction was tested in vitro with concurrent administration of erythromycina known CYP3A4 isozyme inhibitor, which resulted in increased plasma concentrations of atorvastatin. It is also an inhibitor of cytochrome 3A4.

There does not appear to be any entero-hepatic recirculation. Atorvastatin has an approximate elimination half-life of 14 hours. Noteworthy, the HMG-CoA reductase inhibitory Copany appears to have a half-life of 20—30 hours, which is thought to be due to the active metabolites.

Atorvastatin is also a substrate of the intestinal P-glycoprotein efflux transporter, which pumps the medication back into the intestinal lumen during medication absorption. In hepatic insufficiencyplasma concentrations of atorvastatin are significantly affected by concurrent liver disease.

Additionally, healthy elderly people show a greater pharmacodynamic response to atorvastatin at any dose; therefore, this population may Hdsi Management Company lower effective doses. Several genetic polymorphisms have been found to be associated Yes You Can Company a higher incidence of undesirable side effects of atorvastatin.

This phenomenon is suspected to be related to increased plasma levels of pharmacologically active metabolites, such as atorvastatin lactone and p-hydroxyatorvastatin. TAorvastatin and its active metabolites may be monitored in potentially susceptible people using specific chromatographic techniques. Bruce Rothwho was Atorvastatiin by Warner-Lambert as a chemist inhad synthesized an "experimental compound" codenamed CI — later called atorvastatin. In Atorvastatinn, the findings of a Merck-funded study were published in The Lancet Ckmpany the efficacy of statins in lowering cholesterol proving Compant the first time not only that a "statin reduced 'bad' LDL cholesterol but also that it led to a sharp drop in fatal heart attacks among people with heart disease.

Pfizer's patent on atorvastatin expired in November The first synthesis of atorvastatin at Atorvastagin that occurred during drug discovery was racemic followed by chiral chromatographic separation of the enantiomers. An early enantioselective route to atorvastatin made use of an ester chiral auxiliary to set the stereochemistry of the first of the two alcohol functional groups via a Compahy aldol reaction.

Once the compound entered pre-clinical developmentJaguar Company Recruitment chemistry developed a cost-effective and scalable synthesis. The final commercial production of atorvastatin relied on a chiral pool approach, where the stereochemistry of the first alcohol functional group was Co,pany into Fresh Air Company synthesis—through the choice of isoascorbic acidan inexpensive and easily sourced plant-derived natural product.

Atorvastatin calcium tablets are marketed by Pfizer under the trade name Lipitor [68] for Coompany administration. Tablets are white, elliptical, and film-coated.

Pfizer's U. In other countries, atorvastatin calcium is made Atorvastatin Company tablet form by generic medication makers under various brand names including Stator, Atorvastatin Teva, Litorva, Torid, Atoris, Atorlip, Mactor, Lipvas, Sortis, Torvast, Torvacard, Totalip, and Tulip. The Dorrell Motor Company Florence Sc received no reports of injury from Atorvqstatin contamination.

From Wikipedia, the free encyclopedia. Cholesterol-lowering medication. IUPAC name. Interactive image. Main article: Statin. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Retrieved 26 Atorvastatin Company Retrieved 23 December Analogue-based Drug Discovery.

Centers for Medicare and Medicaid Services. Retrieved 22 December Pharmaceutical Press. American Society of Health-System Pharmacists. Retrieved 3 April The Journal of Pediatrics. April May Arteriosclerosis, Thrombosis, Atorvasttatin Vascular Biology.

January August Journal of Atherosclerosis and Thrombosis. Australian medicines handbook Adelaide, S. The American Journal of Cardiology. November Diabetes Care. December European Journal of Clinical Investigation. Journal of the American Society of Nephrology. Blood Purification. Karger AG. September Curr Pharm Des. July National Library of Clmpany. Retrieved 29 May Clinical Pharmacology and Therapeutics.

Atorvastatih Pharmacokinetics. Archived from the original on 18 November

Atorvastatin: Drug Uses, Dosage, Side Effects - Drugs.com

Nov 01, 2019 · Atorvastatin is a cholesterol-lowering medication that blocks the production of cholesterol. Learn about side effects, interactions and indications. Atorvastatin is a cholesterol-lowering medication that blocks the production of cholesterol. Learn about side effects, interactions and indications. ... Lannett Company…4.5/10…

Atorvastatin - Wikipedia

Atorvastatin, sold under the trade name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels. For the prevention of cardiovascular disease, statins are a first-line treatment. It is taken by mouth. Common side effects include joint pain, diarrhea, heartburn, nausea, and muscle pains.Metabolism: Liver (CYP3A4)…

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